From sequence-defined RNA strands to programmable, multifunctional nanoparticles
RNA is more than a therapeutic cargo. It can also be the material that builds the delivery system.
Our platform combines chemical RNA synthesis, site-specific modification, purification, conjugation, self-assembly, and nanoparticle quality control in one connected workflow. The result is a modular system in which structure, targeting, imaging, and therapeutic function can be designed together from the beginning.
Fundamental Concepts
Explore RNA & Nanoparticles
What Is RNA?
RNA, or ribonucleic acid, is a biological molecule made from four nucleotide building blocks: adenine, uracil, guanine, and cytosine. It is usually single-stranded. However, parts of the strand can pair with one another and fold into helices, loops, junctions, and other three-dimensional structures. RNA contains a 2′ hydroxyl group that makes it chemically different from DNA and more sensitive to degradation.
RNA does more than carry genetic information from DNA. It can regulate genes, recognize proteins and cells, bind complementary nucleic acids, and in some cases catalyze reactions. Because its sequence determines both its structure and function, RNA can be programmed as a therapeutic molecule, targeting element, sensor, or building material for nanoparticles.
Our Custom and Modified RNA
We prepare sequence-defined RNA strands using solid-phase phosphoramidite chemistry. This approach allows nucleotides and chemical functionalities to be placed at specific positions within the RNA:
Unlike enzymatic transcription, which depends on a DNA template and RNA polymerase, chemical synthesis builds the RNA nucleotide by nucleotide. This provides greater control over sequence composition and the exact position of chemical modifications.
Automated solid-phase synthesis enables single-nucleotide precision
Synthetic RNA and RNA Nanoparticle Production Platform
Key Features of Our Synthetic RNA & Nanoparticle Platform
Our integrated production platform combines sequence and architecture design, automated solid-phase RNA synthesis, site-specific chemical modification, purification, conjugation, and controlled self-assembly to generate defined RNA strands and multifunctional RNA nanoparticles. The workflow is designed for research and preclinical applications that require precise placement of stabilizing nucleotides, reactive handles, targeting modules, imaging labels, therapeutic oligonucleotides, or small-molecule drugs within a reproducible RNA construct.
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Sequence-Guided RNA and Nanoparticle Design
Automated Solid-Phase RNA Synthesis
Site-Specific Chemical Modification
Controlled Cleavage, Deprotection, and Purification
Drug, Ligand, and Fluorophore Conjugation
Programmable RNA Nanoparticle Assembly
Comprehensive Quality Assessment
Sequence-Guided RNA and Nanoparticle Design
Each project begins with the required biological function and the final molecular format. RNA length, junction geometry, complementary regions, modification sites, targeting modules, and therapeutic cargo are considered together. This approach helps ensure that each strand can be synthesized efficiently and can still fold or assemble correctly after modification.
Sequence-Guided RNA and Nanoparticle Design
Each project begins with the required biological function and the final molecular format. RNA length, junction geometry, complementary regions, modification sites, targeting modules, and therapeutic cargo are considered together. This approach helps ensure that each strand can be synthesized efficiently and can still fold or assemble correctly after modification.
Explore In-Depth Platforms
Dedicated RNA Technology Sub-Platforms
Integrated RNA Preparation Platform
8-stage solid-phase chemical RNA synthesis, purification strategies (PAGE, RP-HPLC, AX-HPLC), small-molecule click conjugation, and post-purification QC.
Synthetic RNA Nanoparticle Platform
Programmable 3WJ, 4WJ, and 6WJ architectures, multi-junction self-assembly protocols, published preclinical proof points, and multivalent payload delivery.