Products & Services

Custom RNA Strands

Precision synthesis of tailored RNA sequences with advanced chemistry, site-specific drug conjugation, and fluorescent labeling for research, diagnostics, and therapeutics.

What We Offer

Tailored RNA for Your Exact Specifications

✓ Precise control over sequence, length, modification type, and modification placement.
✓ Site-specific drug conjugation for the development of RNA–drug conjugates and multifunctional RNA constructs.
✓ Fluorescent labeling with commonly used fluorophores for imaging, tracking, detection, and quantitative assays.
✓ Incorporation of functional groups, linkers, targeting ligands, and other chemical modifications to support downstream conjugation and assembly.
✓ Purification and quality assessment selected according to construct complexity and project requirements.

Applications

Built for Diverse Applications

✓ Molecular biology and RNA structure–function studies.
✓ Gene-expression, RNA-interference, and target-validation research.
✓ Programmable RNA nanostructure design and assembly.
✓ RNA–drug conjugation for targeted drug delivery, therapeutic development, and drug-delivery research.
✓ Fluorescence tracking, molecular-binding, and cellular-uptake studies.

Custom Synthesis & Ordering

Custom RNA Strand Ordering System

Select your synthesis SKU, customize base modifications, enter your RNA sequence (20–128 nt), and configure site-specific drug conjugation and fluorescent labeling.

Select an SKU *

Item Name * Min 6 letters

Minimum requirement of 6 alphabetic letters (A–Z).

Base Modification

Click to insert LNA, 2′-F, Propargyl or PS.

Enter Sequence * 0 bases

Keyboard typing strictly accepts RNA bases A, G, C, U. Lowercase letters are automatically capitalized. Other characters (e.g. 'T', 'M') are automatically erased. Modified bases must be selected from the Base Modification table.

There are 0 bases in this sequence. (Range: 20–128)

Output Sequence (Live Mirror) Empty

—

Scale

1 µmol

Automatically set by SKU

Formulation Option *

Click to confirm dry formulation

Purification Services *

Advanced Engineering

Optional Customization

Choose Drug Conjugation, Fluorescent Labeling, or both. These options are not mutually exclusive.

Drug Conjugation Configuration

Site-specific attachment using click-compatible propargyl modifications.

Active

Select Drug Molecule *

Number of Drugs Per Strand *

Up to 7 drug molecules per strand, depending on available propargyl sites.

Linker Chemistry *

Fluorescent Labeling Configuration

Select validated fluorophores and terminal or internal labeling positions.

Active

Select Fluorophore Range *

Select	Range	Fluorophore Name	Approx. Excitation Max	Approx. Emission Max
✓	Green	6-FAM	495 nm	520–521 nm
✓	Yellow	HEX	537 nm	556 nm
✓	Yellow	Yakima Yellow	530 nm	549 nm
✓	Far-red	Cyanine5	646 nm	662 nm
✓	Near-infrared	Cyanine7	750 nm	773 nm
✓	Near-infrared	Cyanine7.5	788 nm	808 nm

Number of Labels *

Labeling Position *

Requested Internal Labeling Position *

Requested Internal Labeling Positions (Two Internal Sites) *

Position 1

Position 2

Order Summary

CRS-1000

Output Sequence:

—

Sequence length: 0 nucleotides

Standard nucleotides: 0

2′-F modifications: 0

LNA modifications: 0

Propargyl modifications: 0

Phosphorothioate linkages: 0

Scale: 1 µmol

Formulation: None selected

Purification: None selected

Custom synthesis specification review • Pricing provided upon submission

Base Modifications

Select a modified base to insert at the current cursor position in your RNA sequence.

Modification Type	Code	Action
LNA-A LNA	(A+)
LNA-C LNA	(C+)
LNA-G LNA	(G+)
LNA-T LNA	(T+)
2′-F Adenosine 2′-F	(AF)
2′-F Cytidine 2′-F	(CF)
2′-F Guanosine 2′-F	(GF)
2′-F Uridine 2′-F	(UF)
Propargyl-A Propargyl (Drug click site)	(AP)
Propargyl-C Propargyl (Drug click site)	(CP)
Propargyl-G Propargyl (Drug click site)	(GP)
Propargyl-U Propargyl (Drug click site)	(UP)
A with phosphorothioate linkage Phosphorothioate	(AS)
C with phosphorothioate linkage Phosphorothioate	(CS)
G with phosphorothioate linkage Phosphorothioate	(GS)
U with phosphorothioate linkage Phosphorothioate	(US)

Each bracketed modification counts as exactly 1 nucleotide in length.